Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths.
Identifieur interne : 000633 ( new/Analysis ); précédent : 000632; suivant : 000634Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths.
Auteurs : Chih-Cheng Lai [Taïwan] ; Yen Hung Liu [Taïwan] ; Cheng-Yi Wang [Taïwan] ; Ya-Hui Wang [Taïwan] ; Shun-Chung Hsueh [Taïwan] ; Muh-Yen Yen [Taïwan] ; Wen-Chien Ko [Taïwan] ; Po-Ren Hsueh [Taïwan]Source :
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [ 1995-9133 ] ; 2020.
Abstract
Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel coronavirus [2019-nCoV]) in Wuhan, China in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 75,000 cases have been reported in 32 countries/regions, resulting in more than 2000 deaths worldwide. Despite the fact that most COVID-19 cases and mortalities were reported in China, the WHO has declared this outbreak as the sixth public health emergency of international concern. The COVID-19 can present as an asymptomatic carrier state, acute respiratory disease, and pneumonia. Adults represent the population with the highest infection rate; however, neonates, children, and elderly patients can also be infected by SARS-CoV-2. In addition, nosocomial infection of hospitalized patients and healthcare workers, and viral transmission from asymptomatic carriers are possible. The most common finding on chest imaging among patients with pneumonia was ground-glass opacity with bilateral involvement. Severe cases are more likely to be older patients with underlying comorbidities compared to mild cases. Indeed, age and disease severity may be correlated with the outcomes of COVID-19. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. Currently, effective infection control intervention is the only way to prevent the spread of SARS-CoV-2.
DOI: 10.1016/j.jmii.2020.02.012
PubMed: 32173241
Affiliations:
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Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Section of Infectious Diseases, Taipei City Hospital, Taipei, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Ko, Wen Chien" sort="Ko, Wen Chien" uniqKey="Ko W" first="Wen-Chien" last="Ko">Wen-Chien Ko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medicine, College of Medicine, National Cheng Kung University, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: hsporen@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi</title><idno type="eISSN">1995-9133</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel coronavirus [2019-nCoV]) in Wuhan, China in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 75,000 cases have been reported in 32 countries/regions, resulting in more than 2000 deaths worldwide. Despite the fact that most COVID-19 cases and mortalities were reported in China, the WHO has declared this outbreak as the sixth public health emergency of international concern. The COVID-19 can present as an asymptomatic carrier state, acute respiratory disease, and pneumonia. Adults represent the population with the highest infection rate; however, neonates, children, and elderly patients can also be infected by SARS-CoV-2. In addition, nosocomial infection of hospitalized patients and healthcare workers, and viral transmission from asymptomatic carriers are possible. The most common finding on chest imaging among patients with pneumonia was ground-glass opacity with bilateral involvement. Severe cases are more likely to be older patients with underlying comorbidities compared to mild cases. Indeed, age and disease severity may be correlated with the outcomes of COVID-19. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. Currently, effective infection control intervention is the only way to prevent the spread of SARS-CoV-2.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lai, Chih Cheng" sort="Lai, Chih Cheng" uniqKey="Lai C" first="Chih-Cheng" last="Lai">Chih-Cheng Lai</name></noRegion><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><name sortKey="Hsueh, Shun Chung" sort="Hsueh, Shun Chung" uniqKey="Hsueh S" first="Shun-Chung" last="Hsueh">Shun-Chung Hsueh</name><name sortKey="Ko, Wen Chien" sort="Ko, Wen Chien" uniqKey="Ko W" first="Wen-Chien" last="Ko">Wen-Chien Ko</name><name sortKey="Liu, Yen Hung" sort="Liu, Yen Hung" uniqKey="Liu Y" first="Yen Hung" last="Liu">Yen Hung Liu</name><name sortKey="Wang, Cheng Yi" sort="Wang, Cheng Yi" uniqKey="Wang C" first="Cheng-Yi" last="Wang">Cheng-Yi Wang</name><name sortKey="Wang, Ya Hui" sort="Wang, Ya Hui" uniqKey="Wang Y" first="Ya-Hui" last="Wang">Ya-Hui Wang</name><name sortKey="Yen, Muh Yen" sort="Yen, Muh Yen" uniqKey="Yen M" first="Muh-Yen" last="Yen">Muh-Yen Yen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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